The 5th PROFID General Assembly Meeting took place on the 31st of March 2022 and involved 55 consortium members. The goal of the two-hour online meeting was to share with the partners the latest breakthroughs in the development of the PROFID clinical prediction model, with a focus on the extensive re-analysis of the CMR datasets. It was a great occasion to acknowledge the progress made in the first 27 months of the project, and gave the participants the opportunity to discuss the latest results, future steps and implications for the clinical trials in the PROFID project.