Implementation of personalised risk prediction and prevention of sudden cardiac death after myocardial infarction

Personalised prevention of sudden cardiac death: from analysis of existing data to large trials

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 847999.

PROFID AT EHRA 2023

We had the great opportunity to present PROFID to world-leading cardiology experts at the EHRA Congress 2023 in Barcelona.

Gerhard Hindricks gave a presentation about the “Generation of novel randomized evidence for the role of primary prevention ICD under contemporary treatment”, in which he showed once again why the PROFID project is urgently needed for the improvement of patient care.

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Interview – THE PROFID CLINICAL TRIAL

After extensive 2.5 years, the PROFID data analysis has been completed. The results, which were presented at the ESC Congress 2022 in Barcelona, have significant implications for the setup of the randomized trial programme. We are currently finalizing an updated design of the PROFID clinical trial, in order to start the submissions to the Ethics Committees at the beginning of 2023.

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CONDUCTING THE PROFID TRIAL

The Clinical Research Institute in Munich, Germany, is a full-service Contract Research Organisation (CRO) specialized in large international, commercial and non-commercial (academic) clinical studies in Europe covering both, drug trials and medical device studies.

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PROFID at ESC 2022

This year, PROFID had a marked presence at the European Society of Cardiology 2022 Congress, the world’s largest cardiovascular congress, during the session “Latest Science in Arrhythmias”. Project coordinator Dr. Nikolaos Dagres of the Leipzig Heart Institute presented the final results of the PROFID analysis.

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ESC/ EHRA – engaged to reduce the burden of cardiovascular diseases

The European Association of Cardiology (ESC) is an independent, non-profit organisation and represents more than 95,000 decision-makers and healthcare professionals in the field of cardiology. The ESC acts in the interest of patients by providing cardiologists with the support and tools they need to deliver the best possible care.

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Interview – THE PROFID CMR RE-ANALYSIS

In phase one of the development of the PROFID risc prediction model we analysed 19 datasets from Europe, Israel and the US, based on a collection of existing highly phenotyped data with the largest number of post-MI patients (~225,000 observations).

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EHRA 2022 CONGRESS OUTCOMES

PROFID was featured prominently in two separate sessions at the European Heart Rhythm Association congress – EHRA 2022 in Copenhagen (3 April – 5 April 2022).

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PROFID at EHRA 2022

We are proud to announce that PROFID has been selected for a Late Breaking Science session at the EHRA 2022 congress in Copenhagen. Dr. Nikolaos Dagres will give a presentation on Sunday, April 3rd at 1:55 pm CET in Room 1.

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Interview University of Manchester

Prof. Peek from the University of Manchester is leading Work Package 1 “Risk Score Development” of PROFID. Together with his team he analysed 19 data sets (from more than 200.000 patients) to develop a new model for predicting the risk of sudden cardiac death after myocardial infarction.

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Addressing unmet patient needs

Patients can make a valuable contribution and improve societal impact through their engagement in research projects. In implementing its work, PROFID ensures that patients’ perspective is included through the project partner German Heart Foundation.

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PROFID at ESC 2021

This year, PROFID had a presence at the European Society of Cardiology 2021 Congress during the session ‘Latest Science in Arrhythmias and Device Therapy’.

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BMJ Open Heart

Ethical issues in two parallel trials of personalised criteria for implantation of implantable cardioverter defibrillators for primary prevention: the PROFID project

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PROFID at EHRA 2021

The EHRA 2021 congress is the annual scientific meeting of the project partner European Heart Rhythm Association (EHRA). The online congress was held between Friday 23 April and Sunday 25 April 2021.

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3rd General Assembly Meeting

PROFID hosted its 3rd General Assembly Meeting on the 5th of March 2021. In this 5 hours online meeting, 56 members of the consortium discussed the project progress and the milestones reached in the first 14 month.

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Paper: The PROFID project

A large European effort towards personalized prediction and prevention of sudden cardiac death after myocardial infarction funded by the European Union

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Launch of PROFID

PROFID’s was funded by the European Commission over the Horizon 2020 programme under grant agreement no. 847999. The project has started on 1st January 2020.

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