Implementation of personalised risk prediction and prevention of sudden cardiac death after myocardial infarction

We had the great opportunity to present PROFID to world-leading cardiology experts at the EHRA Congress 2023 in Barcelona.

Gerhard Hindricks gave a presentation about the “Generation of novel randomized evidence for the role of primary prevention ICD under contemporary treatment”, in which he showed once again why the PROFID project is urgently needed for the improvement of patient care.

In a news article released in March 2023, Dr. Nikolaos Dagres and Prof. Gerhard Hindricks, chief investigators and coordinators of the PROFID project, present new strategies in order to reassess the role of routine prophylactic defibrillator implantation for primary prevention of SCD.

After extensive 2.5 years, the PROFID data analysis has been completed. The results, which were presented at the ESC Congress 2022 in Barcelona, have significant implications for the setup of the randomized trial programme. We are currently finalizing an updated design of the PROFID clinical trial, in order to start the submissions to the Ethics Committees at the beginning of 2023.

The Clinical Research Institute in Munich, Germany, is a full-service Contract Research Organisation (CRO) specialized in large international, commercial and non-commercial (academic) clinical studies in Europe covering both, drug trials and medical device studies.

This year, PROFID had a marked presence at the European Society of Cardiology 2022 Congress, the world’s largest cardiovascular congress, during the session “Latest Science in Arrhythmias”. Project coordinator Dr. Nikolaos Dagres of the Leipzig Heart Institute presented the final results of the PROFID analysis.

The 6th PROFID Consortium Meeting was held on 26th of July 2022.

The European Association of Cardiology (ESC) is an independent, non-profit organisation and represents more than 95,000 decision-makers and healthcare professionals in the field of cardiology. The ESC acts in the interest of patients by providing cardiologists with the support and tools they need to deliver the best possible care.

In phase one of the development of the PROFID risc prediction model we analysed 19 datasets from Europe, Israel and the US, based on a collection of existing highly phenotyped data with the largest number of post-MI patients (~225,000 observations).

PROFID was featured prominently in two separate sessions at the European Heart Rhythm Association congress – EHRA 2022 in Copenhagen (3 April – 5 April 2022).

The 5th PROFID General Assembly Meeting took place on the 31st of March 2022 and involved 55 consortium members.

We are proud to announce that PROFID has been selected for a Late Breaking Science session at the EHRA 2022 congress in Copenhagen. Dr. Nikolaos Dagres will give a presentation on Sunday, April 3rd at 1:55 pm CET in Room 1.

Prof. Peek from the University of Manchester is leading Work Package 1 “Risk Score Development” of PROFID. Together with his team he analysed 19 data sets (from more than 200.000 patients) to develop a new model for predicting the risk of sudden cardiac death after myocardial infarction.

Patients can make a valuable contribution and improve societal impact through their engagement in research projects. In implementing its work, PROFID ensures that patients’ perspective is included through the project partner German Heart Foundation.

This year, PROFID had a presence at the European Society of Cardiology 2021 Congress during the session ‘Latest Science in Arrhythmias and Device Therapy’.

The 4th General Assembly Meeting was held on the 24th of August 2021.

Ethical issues in two parallel trials of personalised criteria for implantation of implantable cardioverter defibrillators for primary prevention: the PROFID project

An interview with Professor Dr. Gerhard Hindricks and PD Dr. Nikolaos Dagres.

On 30 April 2021, the University of Manchester hosted a first workshop with contributions from the Leipzig Heart Institute.

The EHRA 2021 congress is the annual scientific meeting of the project partner European Heart Rhythm Association (EHRA). The online congress was held between Friday 23 April and Sunday 25 April 2021.

The 2nd PROFID General Assembly meeting took place on the 30th of September 2020. Due to the COVID-19 pandemic, this meeting was held completely online.

A large European effort towards personalized prediction and prevention of sudden cardiac death after myocardial infarction funded by the European Union

The PROFID Kick-off meeting took place on 19th and 20th of February 2020 in Berlin, Germany.

PROFID’s was funded by the European Commission over the Horizon 2020 programme under grant agreement no. 847999. The project has started on 1st January 2020.